GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs3126085 | 1 | rs4845756 | chr1:152254919 | HRNR | chr1:152184558-152196669:- | 0.5 | 7.22 | 2.04E-12 | Atopic dermatitis |
| THCA | cis | rs17401966 | 1 | rs4845934 | chr1:10468946 | KIF1B | chr1:10270764-10441659:+ | 0.21 | 6.36 | 4.74E-10 | Hepatocellular carcinoma |
| THCA | cis | rs17401966 | 1 | rs4846208 | chr1:10313839 | KIF1B | chr1:10270764-10441659:+ | 0.21 | 6.36 | 4.75E-10 | Hepatocellular carcinoma |
| THCA | cis | rs17401966 | 1 | rs4846210 | chr1:10322153 | KIF1B | chr1:10270764-10441659:+ | 0.21 | 6.36 | 4.75E-10 | Hepatocellular carcinoma |
| THCA | cis | rs6546537 | 1 | rs4852892 | chr2:69866769 | AAK1 | chr2:69685127-69870977:- | -0.23 | -4.71 | 3.19E-6 | Serum thyroid-stimulating hormone levels |
| THCA | cis | rs4853036 | 1 | rs4853036 | chr2:70059824 | SNRNP27 | chr2:70121090-70132348:+ | 0.18 | 4.59 | 5.6E-6 | Colorectal or endometrial cancer |
| THCA | cis | rs5743030 | 1 | rs4853634 | chr2:190779231 | ASNSD1 | chr2:190526125-190535556:+ | -0.58 | -6.01 | 3.77E-9 | Subcutaneous adipose tissue |
| THCA | cis | rs13424612 | 1 | rs4854058 | chr2:240923677 | NDUFA10 | chr2:240900158-240964798:- | 0.3 | 8.47 | 3.1E-16 | Odorant perception (isobutyraldehyde) |
| THCA | cis | rs477692 | 1 | rs485576 | chr10:131425496 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.84 | 1.57E-28 | Response to temozolomide |
| THCA | cis | rs9876781 | 1 | rs4858793 | chr3:48415007 | ATRIP | chr3:48488141-48507708:+ | -0.16 | -3.53 | 0.000452 | Longevity |
| THCA | cis | rs9876781 | 1 | rs4858793 | chr3:48415007 | TREX1 | chr3:48501186-48509043:+ | 0.23 | 5.26 | 2.2E-7 | Longevity |
| THCA | cis | rs9876781 | 1 | rs4858817 | chr3:48416756 | ATRIP | chr3:48488141-48507708:+ | -0.18 | -3.98 | 8.05E-5 | Longevity |
| THCA | cis | rs9876781 | 1 | rs4858817 | chr3:48416756 | TREX1 | chr3:48501186-48509043:+ | 0.24 | 5.62 | 3.17E-8 | Longevity |
| THCA | cis | rs8180040 | 1 | rs4858888 | chr3:47405305 | C3orf75 | chr3:47537131-47555199:- | 0.1 | 4.39 | 1.41E-5 | Colorectal cancer |
| THCA | cis | rs8180040 | 1 | rs4858888 | chr3:47405305 | NBEAL2 | chr3:47021173-47051193:+ | 0.12 | 3.66 | 0.000276 | Colorectal cancer |